Quantitative Analysis of Left Ventricular Deformation After Immunoadsorption Therapy for Patients with Dilated Cardiomyopathy and Severe Congestive

对有限数量的扩张型心肌病（DCM）患者进行的各种研究。然而，斑点追踪超声心动图（STE）对IA治疗后左室整体和局部功能的了解甚少，其准确性已被艾德证实。对照组6例DCM患者（纽约心脏协会III ~ IV级，LVEF < 35%）均行标准、多普勒血流及STE检查。使用基底、中间、心尖短轴视图和心尖3视图检查周向、径向和纵向应变以及LV扭转。分别于治疗前、治疗后1周、1个月、3个月、6个月和12个月进行超声心动图检查。在12个月的随访中，LVEF无显著差异（术前30.67 ± 8.1，1个月29.17 ± 7.1，p = NS），LV舒张末期容积（术前164.0 ± 90.2，1个月138.5 ± 57.9，p = NS），LV收缩末期容积（术前115.7 ± 73.4，1个月90.8± 56.4，p = NS）。至于STE值，在纵向、周向和径向应变以及LV扭转方面也没有显著差异。总之，IA治疗未改善DCM患者的LVEF、LV容积、LV纵向、周向和径向应变以及LV扭转。

Various studies with a limited number of patients suffering from dilated cardiomyopathy (DCM). However little is known about the global and regional LV function after IA therapy using speckle tracking echocardiography (STE), which has been validat ed the accuracy compared with LVEF. Consecutive 6 patients with DCM (New York Heart Association III-IV, LVEF < 35%) underewent standard, Doppler flow, and STE. Basal, mid-, apical short axis views and apical 3 views were used to examine circumferential, radial, and longitudinal strains and LV torsion. Echocardiographic assesment was perfomed at baseline, 1 week, 1, 3, 6, and 12 months after IA therapy. During 12-month follow-up, there were no significant differences in LVEF (pre 30.67 ± 8.1, 1 month 29.17 ± 7.1, p = NS), LV end-diastolic volume (pre 164.0 ± 90.2, 1 month 138.5 ± 57.9, p = NS), LV end-systolic volume (pre 115.7 ± 73.4, 1month 90.8± 56.4, p = NS). As to the values of STE , there were also no significant differences in longitudinal, circumferential, and radial strain and LV torsion. In conclusion, IA therapy did not improve LVEF, LV volume, LV longitudinal, circumferential, and radial strain and LV torsion in DCM.