Osteopontin in the pathogenesis of acute eosinophilic pneumonia

本研究表明，急性嗜酸性粒细胞肺炎和其他类型嗜酸性粒细胞肺炎患者的BALF中骨桥蛋白显著升高。这表明骨桥蛋白升高可能与嗜酸性粒细胞炎症有关。骨桥蛋白的浓度与引起嗜酸性炎症的几种细胞因子和趋化因子的浓度相关。双免疫荧光标记显示肺嗜酸性粒细胞中有骨桥蛋白表达。骨桥蛋白可能参与急性嗜酸性肺炎患者嗜酸性粒细胞炎症的发展。

The present study demonstrated that osteopontin was significantly elevated in BALF from patients with acute eosinophilic pneumonia as well as other types of eosinophilic pneumonia. This suggests that osteopontin elevation may be associated with eosinophilic inflammation. The concentration of osteopontin was correlated with that of several cytokines and chemokines, which induce eosinophilic inflammation. Double immunofluorescence labeling showed that osteopontin was expressed in lung eosinophils.Osteopontin may contribute to the development of eosinophilic inflammation in patients with acute eosinophilic pneumonia.