Regulatory mechanisms of hepcidin, the central regulator of body iron homeostasis

本研究的目的是通过对铁代谢相关分子如hepcidin和铁蛋白的基础和临床研究来阐明铁疾病的发病机制。我们发现肝癌细胞的hepcidin表达受微环境ph的影响。我们还发现铁储存蛋白h -铁蛋白通过转铁蛋白受体1被红细胞选择性摄取。此外，我们证明移植前高铁蛋白血症是同种异体干细胞移植后细菌感染和疾病复发的危险因素。

The purpose of this study was to clarify the pathogenesis of iron disorders through basic and clinical studies of iron metabolism-associated molecules such as hepcidin and ferritin. We identified that hepcidin expression by hepatoma cells was affected by microenvironmental pH. We also found that iron storage protein H-ferritin was selectively taken up by erythroid cells through transferrin receptor 1. Furthermore, we demonstrated that pre-transplant hyperferritinemia was a risk factor for bacterial infection and disease relapse after allogenic stem cell transplantation.