Contribution of integrin in the pathogenesis ofrheumatoid arthritis
Contribution of integrin in the pathogenesis ofrheumatoid arthritis
批准号:
22591076
负责人:
KAWANO Seiji
金额:
$2.83万
依托单位:
依托单位国家:
日本
项目类别:
Grant-in-Aid for Scientific Research (C)
财政年份:
2010
资助国家:
日本
项目状态:
已结题
起止时间:
2010 至 2012
中文摘要
我们研究了miRNA在类风湿关节炎发病机制中调控β 1整合素的作用。我们发现(1)miR-124过表达导致RA滑膜细胞β -1整合素表达降低;(2)在大鼠佐剂诱导的关节炎模型中,注射miR-124可改善关节炎,降低关节组织切片β -1整合素表达。
英文摘要
We investigated the roles of miRNA with regard to the regulation of beta1 integrin in the pathogenesis of rheumatoid arthiritis. We found that (1) Overexpression of miR-124 caused lower expression of beta1 integrin in RA synoviocyte cell line, (2) Injection of miR-124 ameliorated the arthritis and reduced beta-1 integrin expression in histological section of joints in rat adjuvant-induced arthritis model.
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MiR-124a as a key regulator of proliferation andMCP1 secretion in synoviocytes from RA patients.
MiR-124a 作为 RA 患者滑膜细胞增殖和 MCP1 分泌的关键调节因子。
DOI:
--
发表时间:
2010
期刊:
影响因子:
--
作者:
[Kameoka J, Takahashi N, Noji H, Murai K, Tajima K, Kameoka Y, Shichishima T, Ishida Y, Harigae H, Sawada K, 長谷英徳, 河野誠司]
通讯作者:
河野誠司
DOI:
10.1016/j.bbrc.2011.12.010
发表时间:
2012-01-06
期刊:
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
影响因子:
3.1
作者:
[Jauharoh, Siti Nur Aisyah, Saegusa, Jun, Kawano, Seiji]
通讯作者:
Kawano, Seiji
Hyperdiploidy and duplication of der(11)ins(10;11)(p12;q23q14) in acute myeloid leukemia with MLL/MLLT10 fusion gene.
MLL/MLLT10 融合基因急性髓系白血病中 der(11)ins(10;11)(p12;q23q14) 的超二倍体和重复。
DOI:
10.3109/10428194.2012.762094
发表时间:
2013
期刊:
Leukemia and Lymphoma.
影响因子:
--
作者:
[Kiyohara C, Washio M, Horiuchi T, Asami T, et al., 小荒田秀一, Yamamoto K]
通讯作者:
Yamamoto K
Trimethoprim-Sulfamethoxazole-Induced Hepatitis in Mixed Connective Tissue Disease.
混合性结缔组织病中甲氧苄氨嘧啶-磺胺甲恶唑诱发的肝炎。
DOI:
--
发表时间:
2011
期刊:
International Journal of Clinical Medicine
影响因子:
--
作者:
[Sugimoto T, Nobuhara Y, Kawano S, and Morinobu A]
通讯作者:
and Morinobu A
DOI:
10.1186/1476-511x-11-146
发表时间:
2012-10-31
期刊:
Lipids in health and disease
影响因子:
4.5
作者:
[Nagata T, Sugiyama D, Kise T, Tsuji S, Ohira H, Sato I, Yamamoto M, Kohsaka H, Kawano S, Yamashita S, Ishikawa Y, Fujioka Y]
通讯作者:
Fujioka Y
共 26 条
MicroRNA profiling of human lupus nephritis and murine lupus-like nephritis.
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批准号:19591167
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项目类别:Grant-in-Aid for Scientific Research (C)
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资助金额:$2.91万
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财政年份:2007
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负责人:KAWANO Seiji
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依托单位:
Research of the roles of PD-1/PD-Ligand in human lupus nephritis and murine lupus-like nephritis
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批准号:17591042
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项目类别:Grant-in-Aid for Scientific Research (C)
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资助金额:$2.24万
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财政年份:2005
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负责人:KAWANO Seiji
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依托单位:
海外基金