The establishment of gadolinium-induced skin fibrosis and calcification mice model.

肾源性系统性纤维化（NSF）是一种获得性疾病，其特征是严重肾功能不全患者的系统性纤维化和异常钙化。越来越多的证据支持这一假设，即用于磁共振成像的含钆（Gd）造影剂触发NSF的发展。本研究旨在建立Gd诱导的小鼠皮肤纤维化和钙化模型。皮下注射骨髓间充质干细胞和载钆水凝胶诱导小鼠皮肤纤维化，但不诱导皮肤钙化。接下来，我们将研究Gd诱导皮肤纤维化的机制。

Nephrogenic systemic fibrosis (NSF) is an acquired disorder characterized by systemic fibrosis and abnormal calcification in patients with severe renal dysfunction. Growing evidence supports the hypothesis that gadolinium (Gd)-containing contrast agents used for magnetic resonance imaging trigger the development of NSF. The aim of this study was to establish the Gd-induced skin fibrosis and calcification mice model. Subcutaneous injection of bone marrow-derived mesenchymal stem cells and Gd-loaded hydorogel induced skin fibrosis in mice, but not skin calcification. Next we will examine the mechanism of Gd-induced skin fibrosis.