Creation of atopic dermatitis model mouse using double knock out mouse

特应性皮炎是一种难治性皮肤病。本病的临床特征是瘙痒性湿疹。这种疾病是由聚丝蛋白基因突变引起的。Loricrin是表皮角质层边缘带的主要成分。临床方面的变异形式Vohwinkel综合征致残性角化皮病与鱼鳞病。这种表型与寻常型鱼鳞病相似。寻常型鱼鳞病是由聚丝蛋白基因的纯合或复合杂合突变引起的。本课题的目的是利用氯霉素敲除小鼠建立特应性皮炎小鼠模型。

Atopic dermatitis is one of intractable skin diseases. The clinical feature of this disease is itchy eczema. This disease is caused by mutations in filaggrin gene now. Loricrin is major constituent of marginal band of epidermal corneocyte. The clinical aspects of the variant form of Vohwinkel syndrome are mutilating keratoderma with ichthyosis. This phenotype is similar to ichthyosis vulgaris. Ichthyosis vulgaris is caused by homozygous or compound heterozygous mutations in the filaggrin gene. The aim of this project is creation of atopic dermatitis mouse model using loricrin knock out mouse.