Genome-wide association study of panic disorder in the Japanese population.

在这项研究中，我们使用Affymetrix Mapping 500K Array或genome-wide Human SNP Array 6.0对两个独立的数据集进行了全基因组关联研究（GWAS）。我们获得了每个GWAS的输入基因型，并对两个GWAS数据集（718例病例和1717例对照）进行了荟萃分析。在随访中，在329例病例和861例对照中检测了12个单核苷酸多态性（snp）。利用GWAS或meta分析结果进行基因本体富集和候选基因分析。我们还对两个GWAS样本进行了多基因评分分析，以检验多基因成分导致PD的假设。我们的研究结果表明，大量的常见变异和小影响共同导致了帕金森病的风险。

In this study, we conducted a genome-wide association study (GWAS) in two independent data sets using the Affymetrix Mapping 500K Array or Genome-Wide Human SNP Array 6.0. We obtained imputed genotypes for each GWAS and performed a meta-analysis of two GWAS data sets (718 cases and 1717 controls). For follow-up, 12 single-nucleotide polymorphisms (SNPs) were tested in 329 cases and 861 controls. Gene ontology enrichment and candidate gene analyses were conducted using the GWAS or meta-analysis results. We also applied the polygenic score analysis to our two GWAS samples to test the hypothesis of polygenic components contributing to PD. Our findings suggest that large sets of common variants of small effects collectively account for risk of PD.