Daikenchuto for preventing postoperative recurrence of Crohn's disease: a preclinical study

克罗恩病（CD）的病变肠段通常表现为反复发作的炎症和溃疡引起的严重粘膜和神经元损伤。我们随后确认肠道血流量减少了大约50%。在这些发现的基础上，我们设计了一种新的手术技术，可以同时保持神经再生和血液流动，并证明其在预防吻合口狭窄方面的治疗潜力。在这项研究中，我们发现daikenchuto （DKT）使血流正常化。我们还证实，DKT在结肠炎模型中特异性抑制TNFα和INFγ的产生，这是CD的所谓病因因素。

Segments of diseased bowel in Crohn's disease (CD) typically show severe mucosal and neuronal damage from recurring episodes of inflammation and ulceration. We have subsequently confirmed approximately 50% decrease in intestinal blood flow. On the basis of these findings, we devised a novel surgical technique that at once preserves neuroregeneration and blood flow, and demonstrated its therapeutic potential in the prevention of anastomotic stenosis. In this study we showed that daikenchuto (DKT) normalizes blood flow. We also confirmed that DKT specifically suppresses TNFα and INFγ production in a colitis model, the purported etiological factors in CD.