The possibility of hepatic regenerative medicine usingadipose tissue-derived mesenchymal stem cell (ADRC)

脂肪组织是成体干细胞的丰富来源，被称为“脂肪来源的再生细胞(ADRC)”，具有沿多个谱系分化的能力。在本研究中，我们通过CXCR4/SDF1轴在体外和体内通过CXCR4/SDF1轴证明ADRCs可以分化为肝细胞样细胞，并通过CXCR4/SDF1轴的营养效应和归巢效应保护肝细胞。

Adipose tissue represents an abundant source of adult stem cells, termed ‘adipose-derived regenerative cells (ADRC)’, with the ability to differentiate along multiple lineage pathways. In this study, we demonstrated that ADRCs could be differentiated into hepatocyte like cells, as well as protected hepatocytes by a trophic effectand a homing effect through CXCR4 / SDF1 axis in vitro and in vivo 70% hepatectomy following ischemia reperfusion rat model.