Analyzing corticobasal network with deep brain stimulation and diffsion tensor imaging

我们已经建立了一种新的功能分析方法，将弥散张量成像、纤维束成像和脑深部刺激的解剖和电生理信息整合到晚期帕金森病患者中。我们清楚地展示了深部脑刺激患者的锥体、锥体外系、脊髓丘脑和丘脑皮质网络的纤维束。通过将电刺激效应映射到纤维束成像和扩散张量成像数据上，我们生成了每个病例的功能神经解剖图谱。并在脑电地形图上分析了脑深部刺激的非运动效应、参与睡眠的神经元网络以及晚期帕金森病的精神症状。

We have established a novel functional analyzing method by integrating anatomical and electrophysiological information from diffusion tensor imaging, fiber tractography, and deep brain stimulation in patients with advanced Parkinson’s disease. We clearly demonstrated the fiber tracts for pyramidal, extrapyramidal, spinothalamic, and thalamocortical netoworks in patients with deep brain stimulation. By mapping the electrical stimulation effects on the fiber tractgraphy and diffusion tensor imaging data, we generated functional neuroanatomical atlases were in each case. Also non-motor effects of deep brain stimulation were analyzed on the map of tractography, neuronal networks involved in sleep and psychiatric symptoms in advanced Parkinson’s disease.