The comprehensive study on diagnosis and treatment of minimal deviation adenocarcinoma and related disease of the cervix

本文对112例宫颈腺癌进行了磁共振成像（MRI）、巴氏细胞学检查和宫颈锥切活检，结果表明：90%以上的腺癌（包括宫颈微偏腺癌（MDA））可与宫颈良性病变（如LEGH）相鉴别。克隆性分析显示，6例与MDA或腺癌相关的LEGH病变中有4例是单克隆的，单克隆LEGH病变的X染色体失活模式与共存的恶性病变相同。STK11突变仅在1例MDA中检出，而在LEGH中未检出。这些结果表明，LEGH的一个子集可能是恶性肿瘤的前兆，包括MDA。

Present study of 112 cases demonstrated that over 90% cases of adenocarcinoma including minimal deviation adenocarcinoma (MDA) could be distinguished from benign lesion of the cervix such as lobular endocervical glandular hyperplasia (LEGH) by magnetic resonance imaging (MRI), Papanicolaou cytology and cone biopsy. The clonality analysis revealed that 4 of 6 LEGH lesions associated with MDA or adenocarcinoma were monoclonal, and the patterns of X chromosome inactivation in monoclonal LEGH lesions were identical to those in coexisting malignant lesions. The mutation of STK11 was only identified in one MDA, but not in LEGH. These results indicated that a subset of LEGH may be a precursor to malignant tumors including MDA.