Etiological mechanisms of anxiety disorders induced by fetal alcohol exposure with special reference to fear condition and dynamics state of serotonin.

以往的研究表明，在脑发育期给予5-羟色胺1A受体激动剂可恢复胎儿酒精暴露（FAE）引起的脑发育异常。此外，我们发现成熟的FAE动物在恐惧状态下血清素的动力学状态被破坏。这些结果提示，FAE可引起中枢神经系统功能异常，主要是通过脑发育期5-HT 1A受体介导的5-HT能功能的降低，而5-HT能功能的长期异常可导致成熟FAE动物的焦虑样行为。

Previous study revealed that abnormalities of brain development induced by fetal alcohol exposure(FAE) were recovered by administration of serotonin 1A receptor agonist during period of brain development. In addition, we found disruption of dynamics state of serotonin under fearful state in mature FAE animals. These results suggest that FAE induces abnormalities of central nerves system via reduction of serotonergic function, mainly meditated by serotonin 1A receptor during period of brain development and prolonged abnormality of 5-HTergic function lead to anxiety-like behavior in mature FAE animals.