Clinical and basic study of the effect of microvascular blood flow to normal tissue radiosensitivity

采用激光多普勒血流仪检测正常皮肤微血管血流在照射前后的变化，并分析其时空变化程度及不良反应。照射皮肤微血管血流的变化与急性不良事件的程度相关，但与非照射皮肤（=正常组织血流）无关。但晚期不良事件如皮下水肿与微血管血流有相关趋势。腮腺功能障碍（口干）与微血管血流无相关性。

Laser Doppler flowmeter was used to measure normal skin microvascular blood flow before and after irradiation, and degrees of spatial and temporal changes and adverse events were also analysed. Changes in the microvascular blood flow of the irradiated skin were associated with the degree of acute adversed event, but not with the non-irradiated skin(=normal tissue blood flow). Although, late adversed event such as subcutaneous edema, had trend of correlation with microvascular blood flow. There was no correlation between parotid gland dysfunction(xerostomia) and microvascular blood flow.