Wavelength dependency of light-induced retinal protection and its molecular mechanisms.

生物对各种内源性和外源性应激的反应主要涉及体内稳态机制。本研究旨在认识视网膜细胞/组织中光氧化应激应激反应的分子机制，并积累可应用于未来项目的视网膜治疗的知识。在大鼠的活体实验中，利用自己建立的实验装置，探索了光照对视网膜损伤的作用谱。在离体实验中，测量了不同类型人工晶状体的透射光谱，并估算了光通过这些晶状体引起的视网膜损伤指数。

Biological responses against various endogenous and exogenous stresses is primarily involved in the homeostatic mechanism in in vivo. This study was conducted to recognize molecular mechanisms of stress response against photooxidative stress in retinal cells/tissues and to accumulate knowledge that can be applied to retinal therapeutics for the future projects. In in vivo experiment using rats, by using the experimental settings established by me, I have explored action spectrums of retinal damage that induced by light exposure. In in vitro experiments, I have measured transmission spectrums of various types of intraocular lenses, and estimated retinal damage indexes that induced by light-pass through these lenses.