Peroxidation of skin lipids : a role of nutraceutical foods as the inhibitor

当皮肤暴露于包括阳光在内的空气环境时，皮肤表面脂质会发生过氧化反应。事实上，我们以前已经发现角鲨烯的过氧化作用发生在人类皮肤表面脂质中。在这项研究中，我们证实了这一发现（皮肤角鲨烯过氧化），并发现角鲨烯氢过氧化物诱导皮肤炎症反应。作为一种预防策略，可以通过使用水稻生育三烯酚来减少炎症。因此，角鲨烯氢过氧化物（皮肤表面脂质的过氧化产物）将被认为是皮肤炎性病症的潜在治疗靶标，并且生育三烯酚具有作为针对皮肤疾病的保护剂的潜在用途。

When skin is exposed to air environment including sunlight, peroxidation of the skin surface lipids can occur. Indeed, we have previously found that peroxidation of squalene occurs in human skin surface lipids. In this study, we confirmed the findings (skin squalene peroxidation), and found that squalene hydroperoxide induces skin inflammatory responses. As a preventive strategy, the inflammation could be reduced via the use of rice tocotrienol. Squalene hydroperoxide (a peroxidation product of skin surface lipids)would therefore be considered a potential therapeutic target for skin inflammatory disorders, and tocotrienol has potential use as a protective agent against skin diseases.