The role of stress proteins in gastrointestinal and respiratory diseases

特发性肺纤维化（IPF）被认为与白细胞的炎症浸润、活性氧（ROS）（尤其是超氧阴离子）诱导的肺损伤和纤维化（胶原沉积）有关。静脉给药PC-SOD可抑制博莱霉素诱导的支气管肺泡灌洗液中白细胞数量的增加。PC-SOD也抑制了博莱霉素诱导的胶原沉积和肺中羟脯氨酸水平的升高，提示PC-SOD抑制博莱霉素诱导的肺纤维化。

Idiopathic pulmonary fibrosis(IPF) is thought to involve inflammatory infiltration of leukocytes, lung injury induced by reactive oxygen species(ROS), in particular superoxide anion, and fibrosis(collagen deposition). Intravenous administration of PC-SOD suppressed the bleomycin-induced increase in the number of leukocytes in bronchoalveolar lavage fluid. Bleomycin-induced collagen deposition and increased hydroxyproline levels in the lung were also suppressed in animals treated with PC-SOD, suggesting that PC-SOD suppresses bleomycin-induced pulmonary fibrosis.