Analysis of Rab35 GTPase: insight into cytoskeletal remodeling and membrane trafficking during phagocytosis

吞噬小体的形成和随后的成熟是一系列复杂的事件，涉及肌动蛋白细胞骨架重塑和膜运输。在本研究中，我们发现RAS相关蛋白Rab35参与了FcγR介导的巨噬细胞吞噬的早期阶段。我们的数据表明，Rab35通过招募ACAP2来调节肌动蛋白依赖的吞噬小体的形成，ACAP2可能通过ARF6控制肌动蛋白重塑和膜运输。

Phagosome formation and subsequent maturation are complex sequences of events that involve actin cytoskeleton remodeling and membrane trafficking. In this study, we found that the Ras-related protein Rab35 is involved in the early stage of FcγR-mediated phagocytosis in macrophages. Our data indicate that Rab35 regulates actin-dependent phagosome formation by recruiting ACAP2, which might control actin remodeling and membrane traffic through ARF6.