Search for metabolic oscillator regulating food anticipatory activity

食物预期活动(FAA)是由摄食时间限制引起的，由大脑中的食物携带振荡器(FEO)调节。该领域最重要的问题之一是FEO的定位和FEO的分子机制。在这项研究中，我们开发了一种自动饲喂装置，使我们能够控制限制饲喂时间。此外，我们将注意力集中在MBH作为FEO的大脑区域，并通过MBH的微阵列分析鉴定了限制摄食反应基因。这一结果对探讨FEO的分子机制具有重要意义。

Food anticipatory activities(FAA) are known to be induced by temporal restriction of feeding, and are regulated by a food-entrainable oscillator(FEO) located in the brain. One of the most important issues in this field is the localization of FEO and the molecular mechanisms of FEO. In this study, we developed an automated feeding apparatus that enables us to control the restricted feeding timing. Furthermore, we focused our attention to MBH as the brain region of FEO, and identified restricted-feeding response genes by microarray analysis of the MBH. The result should be valuable for approaching the molecular mechanisms of FEO.