Induction of hibernation in the rat, a non-hibernator, and its application to therapy for ischemic injury.

极端低温条件将有利于开发新的治疗方法，特别是对于癌症或缺血性疾病的再灌注损伤。本研究旨在开发一种方法，诱导低温，这相当于冬眠动物，在非冬眠动物。在大鼠（非冬眠动物）中，通过吸入麻醉结合动物冷却强制诱导的低温导致当其体温下降约25℃时心脏骤停。而在降温过程中停止吸入麻醉剂，大鼠体温下降幅度小于10℃。

An extreme hypothermic condition would be beneficial for developing new therapies, especially for cancers or reperfusion injury in ischemic diseases. The present study was designed to develop a method for inducing hypothermia, which is equivalent to hibernating animals, in non-hibernators. In rats(non-hibernator), hypothermia forcibly induced by inhalation anesthesia combined with cooling of the animals resulted in cardiac arrest when their body temperatures were dropped around 25℃. In contrast, body temperature of rats can be reduced less than 10℃ when inhalation of the anesthesia was stopped during the cooling process.