Development of the cure by the transgenics using the nano bubble to the Recklinghausen disease

最初，这项研究的目的是开发一种治疗von Reckinghausen病的基因疗法。然而，由于很明显很难将NF-1基因整合到载体中，我们将靶点改为恶性周围神经鞘瘤，并伴有von Reckinghausen病的疾病。我们观察到，通过将干扰素-α和干扰素-γ基因导入从恶性周围神经鞘瘤分离出来的细胞中，细胞数量显著减少。

Initially the aim of this study was development of a gene therapy of von Recklinghausen's disease. However, because it became clear that integration of NF-1 gene into the vector was difficult, we have changed the target to Malignant peripheral nerve sheath tumor (MPNST), complicating disease of von Recklinghausen's disease.We have observed a marked decrease in number of cells by transfection of IFN-α and IFN-γ gene into cells delived from MPNST.