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Is exercise-induced prevention of depression dependent on hepatic VEGF formation via HIF-1α

Is exercise-induced prevention of depression dependent on hepatic VEGF formation via HIF-1α
运动诱发的抑郁症预防是否依赖于通过 HIF-1α 形成肝脏 VEGF
批准号:
22700661
负责人:
NAKAJIMA Sanae
金额:
$2.58万
依托单位国家:
日本
项目类别:
Grant-in-Aid for Young Scientists (B)
财政年份:
2010
资助国家:
日本
项目状态:
已结题
起止时间:
2010 至 2011

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中文摘要
翻译
本研究的目的是探讨运动诱导的促进海马神经发生和预防抑郁是否与依赖肝血管内皮生长因子的海马区血管内皮生长因子信号通路有关。这些预先设定的结果表明,规律的运动通过独立于运动诱导的肝脏血管内皮生长因子增加的海马区血管内皮生长因子信号通路来预防应激诱导的抑郁的发生。
英文摘要
The purpose of this study was to investigate whether exercise-induced enhancement of hippocampal neurogenesis and prevention of depression is attributed to VEGF signaling pathway of hippocampus dependently on hepatic VEGF. The preset findings suggested that regular exercise prevents stress-induced onset of depression via VEGF signaling pathway of hippocampus independently of exercise-induced increase of hepatic VEGF.
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