Association between plasticity of adipose tissue and expression of adrenergic receptor and glucocorticoid receptor

本实验观察了克仑特罗（CLE）和地塞米松（DEX）（1 mg/kg体重/d，连续10天）对大鼠附睾周围（PED）、肾周围（PRE）和棕色脂肪组织中β_1-、β_2-和β_3-肾上腺素能受体（AR）、糖皮质激素受体（GR）和解偶联蛋白（UCP）-1，2，3 mRNA表达的影响。CLE显著降低PED和PRE脂肪组织相对于体重的相对重量，而不改变棕色脂肪组织的相对重量。另一方面，DEX增加PED和棕色脂肪组织的相对重量/体重，并减少PRE脂肪组织的相对重量/体重。上述结果提示，CLE和DEX对β-AR、GR和UCPs mRNA表达及脂肪组织质量的影响与脂肪组织类型有关。

We studied the effects of clenbuterol(CLE) and dexamethasone(DEX)(each dose=1mg/kg body weight per day for 10 days) on the mRNA expressions ofβ_1-,β_2-andβ_3-adrenergic receptor(AR), glucocorticoid receptor and uncoupling protein(UCP)-1, 2 and 3 in periepididymal(PED), perirenal(PRE) and brown adipose tissues. CLE significantly decreased the relative weight of PED and PRE adipose tissues per body weight without changing that of brown adipose tissue. On the other hand, DEX increased the relative weight of PED and brown adipose tissues per body weight, and decreased that of PRE adipose tissue per body weight. These results suggest that the effects of CLE and DEX on the mRNA expressions ofβ-ARs, GR, and UCPs and adipose tissue mass depend on the type of adipose tissues.