Design of Stimuli-Responsive Particles with Tunable Enzymatic Activity

将具有类酶活性的无机纳米颗粒沉积在囊泡状的温敏颗粒上，包括中空二氧化硅颗粒或聚合物凝胶颗粒。首先检查囊泡的二氧化硅涂层，并且溶液pH影响二氧化硅壳的形态。然后将金和二氧化铈纳米颗粒吸附在囊泡上，然后进行二氧化硅涂层。合成的复合粒子可用作生物传感器和具有类酶活性的催化剂。用原位法将铂纳米粒子沉积在聚（N-异丙基丙烯酰胺）凝胶粒子上，复合粒子具有类过氧化氢酶活性。

Inorganic nanoparticles with enzyme-like activity were deposited on thermo-responsive particles that are vesicle-including hollow silica particles or polymer gel particles. Silica coating of vesicles was first examined and solution pH affected the morphology of silica shell. Gold and ceria nanoparticles were then adsorbed on the vesicles, followed by the silica coating. As-synthesized composite particles can be used as biosensors and catalysts with enzyme-like activity. Platinum nanoparticles were deposited on the poly(N-isopropylacrylamide) gel particles with in situ method and the composite particle showed catalase-like enzymatic activity.