Significance of high-resolution CT findings by using densitometry in patient with pulmonary alveolar proteinosis.

使用密度测定法对肺泡蛋白沉着症患者进行高分辨率 CT 结果的意义。

• 批准号: 23591160
• 负责人: ISHII Haruyuki
• 金额: $ 2.75万
• 依托单位: Kyorin University
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for Scientific Research (C)
• 财政年份: 2011
• 资助国家: 日本
• 起止时间: 2011 至 2013
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-23591160/
• 关键词: 肺胞蛋白症; 胸部CT; densitometry; 肺野濃度

The aim of this study was to analyze the lung attenuation of ground glass opacity (GGO) by using densitometry on high-resolution CT in patients with pulmonary alveolar proteinosis (PAP). Five cases were enrolled in this study. Inspiratory thin-slice spiral chest CT scans (Aquilion 64, Toshiba medical systems, Japan) were performed. The mean lung attenuation and whole lung volume varied in each severity of PAP cases. According to the histogram feature, the ratio associated with PAP (defined as the ratio of CT lung volume for GGO divided by total CT lung volume) contributed to differentiate PAP lesion from normal area. GGO for the range of density -850 to -750 HU suggested the lesion of PAP on HRCT and the lung volume in this range showed the greatest degree correlation with the levels of serum KL-6 (r=0.867)and CEA (r=0.616). Although it is very difficult to early diagnose as PAP in generally, these results might be practical radiographic findings of diagnostic procedure for PAP.

本研究的目的是通过高分辨率CT密度定量分析肺泡蛋白沉积症（PAP）患者磨玻璃样阴影（GGO）的肺密度。本研究入组了5例病例。进行吸气薄层螺旋胸部CT扫描（Aquarium 64，Toshiba Medical Systems，Japan）。平均肺密度和全肺容积在不同程度的PAP病例中不同。根据直方图特征，与PAP相关的比值（定义为GGO的CT肺体积除以总CT肺体积的比值）有助于区分PAP病变与正常区域。HRCT上GGO值在-850 ~-750HU范围内提示PAP病变，此范围内肺体积与血清KL-6（r=0.867）、CEA（r=0.616）水平相关性最大。虽然PAP的早期诊断通常很困难，但这些结果可能是PAP诊断程序的实用X线表现。

项目成果

Prognosis of secondary pulmonary alveolar proteinosis complicated with myelodysplastic syndrome. ― Has the complication of pulmonary alveolar proteinosis had major impact on the prognosis of patients with myelodysplastic syndrome? ―

继发性肺泡蛋白沉积症合并骨髓增生异常综合征的预后 ― 肺泡蛋白沉积症的并发症对骨髓增生异常综合征患者的预后是否有重大影响 ―

• 发表时间: 2012
• 作者: Haruyuki Ishii;Ryushi Tazawa;Koh Nakata
• 通讯作者: Koh Nakata

A-54 years-old man with an uncommon cause of left pleural effusion.

一名 54 岁男性，患有罕见的左侧胸腔积液。

• 发表时间: 2012
• 期刊: Chest
• 影响因子: 9.6
• 作者: Koide T;Saraya K;Nakajima A;Kurai D;Ishii H;Goto H.
• 通讯作者: Goto H.

Clinical characteristics of secondary pulmonary alveolar proteinosis complicated with myelodysplastic syndrome in Japan.

日本继发性肺泡蛋白沉积症并发骨髓增生异常综合征的临床特征

• 发表时间: 2013
• 作者: Ishii H;Tazawa R;Inoue Y;Nakata K.
• 通讯作者: Nakata K.

肺胞蛋白症：最新の知見

肺泡蛋白沉积症：最新发现

• 发表时间: 2011
• 期刊: 呼吸器内科
• 作者: Koide T;Saraya K;Nakajima A;Kurai D;Ishii H;Goto H.;十合 晋作;石井晴之
• 通讯作者: 石井晴之

続発性肺胞蛋白症の臨床的特徴―全国調査結果と更なる課題―

继发性肺泡蛋白沉积症的临床特征 - 全国调查结果和进一步的挑战 -

• 发表时间: 2013
• 作者: 十合晋作;高橋和久;石井晴之
• 通讯作者: 石井晴之