Elucidation of recognition and response of intestinal immune cells to microbes in relation to development of immunomodulating functional foods

在这项研究中，我们试图阐明肠道免疫细胞的功能，重点是它们对微生物和微生物成分的反应，以及与开发新型免疫调节功能食品的关系。我们检测了Peyer‘s斑块树突状细胞对多次TLR模拟的抑制反应。我们分析了CD3-IL-2R+细胞，发现它们也存在于肺部，它们对流感病毒感染有反应。我们还检测了口服耐受诱导的调节性T细胞的基因表达。此外，我们还研究了类杆菌诱导免疫球蛋白A的机制。

In this study, we tried to elucidate the functions of intestinal immune cells, focusing on their responses to microbes and microbial components, in relation to development of novel immunomodulating functional foods. We examined the suppressive response of Peyer's patch dendritic cells to multiple TLR simulation. We analyzed CD3-IL-2R+ cells, and found that they were also present in the lungs, and that they responded to influenza virus infection. We also examined gene expression of regulatory T cells induced in oral tolerance. Furthermore, we examined the mechanism of IgA induction by Bacteroides.