Protectivity of extensive infections by a bacterial outer membrane protein glyceraldehyde-3-phosphate dehydrogenase (GAPDH)

以黄尾(Seriola Ququieradiata)为材料，研究了爱德华氏菌(Edwardsiella Tarada)外膜蛋白甘油醛-3-磷酸脱氢酶(GAPDH)对其他疑难鱼类疾病、假结核病和诺卡氏菌病的保护作用。用GAPDH免疫的鱼对这两种疾病都没有表现出足够的保护水平。但对感染诺卡氏菌的鱼体内生长有抑制作用，增加免疫球蛋白的产生，并激活一些免疫活性基因。鱼致病分枝杆菌。被发现是一种可能对人类具有致病性的模式细菌。

Protective effects of an outer membrane protein glyceraldehyde-3-phosphate dehydrogenase (GAPDH) from a bacterium Edwardsiella tarada against other difficult fish diseases, pseudotuberculosis and nocardiosis, was investigated using yellowtail (Seriola quinqueradiata). The fish immunized with GAPDH did not show enough level of protection against both diseases. However, it showed the growth inhibition of infecting Nocardia inside fish body, increased the production of immunoglobulin, and stimulated some immuno-competent genes. Fish pathogenic Mycobacterium sp. was found to be a model bacterium that may show pathogenicity to humans.