Molecular mechanisms of memory B cell differentiation in germinal centers

为了阐明IL-21或Bcl 6在老年中心中产生高亲和力IgG的记忆B细胞和长寿浆细胞的分化中的作用，我们使用了IL-21缺陷型或Bcl 6缺陷型小鼠。使用这些小鼠，我们证明了IL-21对于产生高亲和力IgG的长寿浆细胞的分化是必需的，并且IL-21或Bcl 6抑制IG类转换重组为IgE，并增强产生高亲和力IgG的记忆B细胞和长寿浆细胞的分化。

To elucidate a role of IL-21 or Bcl6 in differentiation of high affinity IgG producing memory B cells and long-lived plasma cells in germinal centers, we used IL-21-deficient or Bcl6-deficient mice. Using these mice, we demonstrated that IL-21 is essential to differentiation of high affinity IgG producing long-lived plasma cells, and that IL-21 or Bcl6 represses the Ig class switch recombination to IgE and augments the differentiation of high affinity IgG producing memory B cells and long-lived plasma cells.