Survival mechanism of memory B cells
Survival mechanism of memory B cells
批准号:
20390139
负责人:
TOKUHISA Takeshi
金额:
$12.65万
依托单位:
依托单位国家:
日本
项目类别:
Grant-in-Aid for Scientific Research (B)
财政年份:
2008
资助国家:
日本
项目状态:
已结题
起止时间:
2008 至 2010
中文摘要
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英文摘要
To elucidate differentiation mechanisms of memory B cells and long-lived plasma cells, we established the culture system to generate germinal center B cells. Using the system, we demonstrated that Bcl6 represses CD63 which recruits CXCR4 to late endosome to express CXCR4 on centroblasts and that the stimulation of plasmablasts with IL-21 generates long-lived plasma cells.
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Roles for Bcl6 in differentiation of germinal center B cells
Bcl6 在生发中心 B 细胞分化中的作用
DOI:
--
发表时间:
2010
期刊:
影响因子:
--
作者:
[Harada M, Obara K, Hirota T, Yoshimoto T, Hitomi Y, Sakashita M, Doi S, Miyatake A, Fujita K, Enomoto T, Taniguchi M, Higashi N, Fukutomi Y, Nakanishi K, Nakamura Y, Tamari M, 近藤克幸, Tadahiro Suenaga, 徳久剛史]
通讯作者:
徳久剛史
高親和性IgE抗体産生細胞の分化とヘルパーT細胞の多様性
高亲和力 IgE 抗体产生细胞的分化和辅助 T 细胞的多样性
DOI:
--
发表时间:
2010
期刊:
影响因子:
--
作者:
[徳久剛史, 有馬雅史]
通讯作者:
有馬雅史
Role for Bcl6 in development and maintenance of germinal center B cells
Bcl6 在生发中心 B 细胞发育和维持中的作用
DOI:
--
发表时间:
2009
期刊:
影响因子:
--
作者:
[Tokuhisa, T.]
通讯作者:
T.
アレルギーは治せるか
过敏能治好吗?
DOI:
--
发表时间:
2010
期刊:
影响因子:
--
作者:
[Nitta T, et al., Tadahiro Suenaga, 徳久剛史]
通讯作者:
徳久剛史
医学部における寄生虫学教育
医学院的寄生虫学教育
DOI:
--
发表时间:
2008
期刊:
影响因子:
--
作者:
[Takahama Y, et al., 徳久剛史]
通讯作者:
徳久剛史
共 22 条
Heterogeneity of naive CD4 T cells
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批准号:25670227
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项目类别:Grant-in-Aid for Challenging Exploratory Research
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资助金额:$2.5万
-
财政年份:2013
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负责人:TOKUHISA Takeshi
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依托单位:
A role of ADAR1 in induction of somatic hypermutation
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批准号:23659239
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项目类别:Grant-in-Aid for Challenging Exploratory Research
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资助金额:$2.41万
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财政年份:2011
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负责人:TOKUHISA Takeshi
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依托单位:
Molecular mechanisms of memory B cell differentiation in germinal centers
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批准号:23390121
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项目类别:Grant-in-Aid for Scientific Research (B)
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资助金额:$12.73万
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财政年份:2011
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负责人:TOKUHISA Takeshi
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依托单位:
A role of Bcl6 in regulation of somatic hypermutation in the immunoglobulin gene
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批准号:18390149
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项目类别:Grant-in-Aid for Scientific Research (B)
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资助金额:$10.7万
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财政年份:2006
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负责人:TOKUHISA Takeshi
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依托单位:
Study for Development and Maintenance of mune Memory
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批准号:15078202
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项目类别:Grant-in-Aid for Scientific Research on Priority Areas
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资助金额:$90.88万
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财政年份:2003
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负责人:TOKUHISA Takeshi
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依托单位:
Induction Mechanisms of Memory T Cells
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批准号:14570276
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项目类别:Grant-in-Aid for Scientific Research (C)
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资助金额:$2.56万
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财政年份:2002
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负责人:TOKUHISA Takeshi
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依托单位:
Development of the gene therapy model for allergic diseases
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批准号:12557046
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项目类别:Grant-in-Aid for Scientific Research (B)
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资助金额:$8.38万
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财政年份:2000
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负责人:TOKUHISA Takeshi
-
依托单位:
Induction mechanisms of B cell self-toleranace
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批准号:11470082
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项目类别:Grant-in-Aid for Scientific Research (B).
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资助金额:$9.54万
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财政年份:1999
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负责人:TOKUHISA Takeshi
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依托单位:
FUNCTIONAR ROFE OF C-FOS IN DIFFERENTIATION AND PROLIFERATION OF MATURE B CELLS
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批准号:09836001
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项目类别:Grant-in-Aid for Scientific Research (C)
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资助金额:$1.92万
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财政年份:1997
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负责人:TOKUHISA Takeshi
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依托单位:
Analysis of biological roles of class II major histocompatibility antigen by anti-sense RNA
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批准号:62480163
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项目类别:Grant-in-Aid for General Scientific Research (B)
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资助金额:$4.35万
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财政年份:1987
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负责人:TOKUHISA Takeshi
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依托单位:
海外基金