Development of therapy targeting lipid mediator-related GPCRs for prevention of bone resorptive diseases

介导细胞信号的脂质被称为脂质介质。许多脂质介质通过G蛋白偶联受体（GPCR）发挥作用。我们已经研究了脂质介质相关的GPCR，防止骨吸收疾病。我们已经报道了TDAG8受体的基因切除加速骨吸收。TDAG 8被认为是脂质的GPCR，通过不同的机制被激活。

Lipids which mediate cell signals are called lipid mediators. Many lipid mediators exert their effects through G-protein coupled receptors (GPCR). We have investigated the lipid mediator-related GPCRs which prevent bone resorptive diseases. We have reported that gene ablation of the receptor of TDAG8 accerates the bone resorption. TDAG8, which has been considered as the GPCR of the lipids, is activated through the different mechanisms.