A novel intervention of phase II cardiac rehabilitation for patients with multiple complications to advance their social reintegration

胰岛素抵抗增加与高血压（HT）和/或血脂异常（DL）患者的运动能力密切相关，因为已知它会损害骨骼肌的能量代谢。为探讨胰岛素抵抗对HT和/或DL患者运动能力的影响，采用心肺运动试验测定HT和DL患者的稳态模型评价率（HOMA-R）、无氧阈摄氧量（VO 2 AT）和峰值摄氧量（VO 2 AT）。运动能力的评估采用实测VO 2与预测VO 2 AT和预测峰值VO 2的比值高HOMA-R组的%VO 2 AT和% peak VO 2显著低于低HOMA-R组与HOMA-R呈负相关（r=0.339，P<0.05; r=0.522，P<0.05）。目前的研究表明，增加胰岛素抵抗降低HT和/或DL患者的运动能力。

Increased insulin resistance is closely correlated with exercise capacity in patients with hypertension (HT) and/or dyslipidemia (DL), because it is known to impair the energy metabolism in skeletal muscles. The aim of this study was to investigate the influence of insulin resistance on exercise capacity in patients with HT and/or DL.Homeostasis model assessment ratio (HOMA-R) was assessed and oxygen uptake (VO2) at anaerobic threshold (VO2 AT) and peak VO2 were measured by cardiopulmonary exercise testing. The exercise capacity was assessed using ratios of measured VO2 to predicted VO2 AT and predicted peak VO2 (%VO2 AT and %peak VO2, respectively).The %VO2 AT and %peak VO2 were significantly lower in the high HOMA-R group than in the low HOMA-R group (P<0.05, respectively), and negatively correlated with HOMA-R (r=0.339, P<0.05 and r=0.522, P<0.05, respectively). The present study showed that increased insulin resistance decreased exercise capacity in patients with HT and/or DL.