Effects of obesity-related genes and lifestyle on the accumulation of visceral fat area

肥胖受到环境和基因的双重影响。候选肥胖相关基因包括封闭B3AR、B2AR和UCP1的基因。然而，肥胖相关基因对内脏脂肪面积（VFA）的影响尚未见报道。我们研究了遗传因素和环境因素在VFA积累中的作用。研究对象为267名年龄在20-72岁之间的日本人（81名男性，186名女性）。通过CT成像、血液样本和问卷调查获得所有受试者的VFA值。根据三种基因的多态性比较VFA的平均值，没有发现多态性之间的显著差异。此外，我们调整了年龄、运动习惯和步行时间的数据，并分析了VFA的平均值，但没有发现显著差异。然而，VFA的显著差异被发现与运动习惯的不同。这表明，增加运动可导致VFA的减少。

Obesity is both environmentally and genetically influenced. Candidate obesity-related genes include those that enclose B3AR, B2AR and UCP1. However, there are no reports on the effects of obesity-related genes on visceral fat area (VFA). We examined the involvement of genetic factors and environmental factors in the accumulation of VFA. The subjects were 267 Japanese (81 men and 186 women) aged 20-72 years old. VFA values by CT imaging, blood samples and questionnaires were obtained from all subjects.A comparison of the mean of VFA according to the polymorphism in three kinds of genes, did not reveal a significant difference among the polymorphism. In addition, we adjusted the data for age, exercise habit and walking time, and analyzed the mean of VFA, but did not find a significant difference. However, a significant difference in VFA was found with differences in exercise habit. It is suggested that increased exercise leads to a decrease of VFA.