Effects of plant polyphenols intake during lactation on glucose and lipid metabolism in offspring exposed with maternal protein restriction

怀孕期间饮食中蛋白质的限制被认为会导致以后肥胖和葡萄糖耐受不良的发展。本研究旨在探讨哺乳期间母体植物多酚摄入对暴露于胎儿营养不良的幼龄和成年后代肝脏中amp活化蛋白激酶（AMPK）磷酸化的影响。哺乳期间母体植物多酚（红豆多酚和白藜芦醇）的摄入增加了后代肝脏中AMPK的磷酸化。结果表明，哺乳期间植物多酚的摄入激活了肝脏AMPK，并可能影响母体蛋白限制下成年后代的糖脂代谢。

Dietary protein restriction during pregnancy is thought to lead to the development of obesity and glucose intolerance in later life. This study was investigated the effects of maternal plant polyphenols intake during lactation affects AMP-activated protein kinase (AMPK) phosphorylation in the liver of young and adult offspring exposed to fetal malnutrition. Maternal plant polyphenols (azuki bean polyphenols and resveratrol) intake during lactation increased AMPK phosphorylation in the liver of offspring. The results suggest that plant polyphenols intake during lactation activate hepatic AMPK and may affect the glucose and lipid metabolism in adult offspring exposed with maternal protein restriction.