The onset-preventing and suppressive effects of antioxidants on non-alcoholic steatohepatitis in mice

非酒精性脂肪性肝炎（NASH）被认为是目前医学上无法控制的重要生活方式相关疾病之一。我们注意到这种疾病的发展伴随着氧化应激，因此对NASH的预防进行了研究，主要集中在疾病模型的开发和抗氧化剂的施用上。证实了在STAM小鼠（一种新的疾病模型）中在相对短的时间内稳定发展的疾病与人类疾病NASH非常相似。我们还使用这些小鼠检查了给予维生素E、氨基酸（异亮氨酸、亮氨酸）和D-阿洛糖（D-葡萄糖的异构体）的效果，发现给予这些物质显著预防了STAM小鼠的肝脏疾病。

Non-alcoholic steatohepatitis (NASH) is considered to be one of the important lifestyle-related diseases that are not currently manageable medically. No definite clinical effects have as yet been recognized.We noted that this disease develops with oxidative stress and thus conducted an examination on NASH prevention focusing mainly on the development of disease models and administration of antioxidants. It was confirmed that the disease which stably develops over a relatively-short time period in STAM mice, a new disease model, is very similar to the human disease NASH. We also examined the effects of administering vitamin E, amino acids (isoleucine, leucine), and D-allose, an isomer of D-glucose, using these mice and found that the administration of these substances significantly prevented liver disorders in STAM mice.