A study of the effect that deoxyribonucrease I induces apotosis in cardiac diseases

我们没有发现脱氧核糖核酸酶I在心脏疾病中诱导细胞凋亡。然后，我们评估了血管痉挛诱发血管痉挛心绞痛(VSAP)患者的乙酰胆碱激发试验后，氧化应激标志物硝基酪氨酸(NT)是否会升高。冠脉痉挛后血清NT水平显著升高，提示血清NT可作为短暂性心肌缺血的生物标志物，并可能参与VSAP的发生发展。

We could not find out that deoxyribonuclease I induce apoptosis in cardiac diseases. Then, we evaluated whether nitrotyrosin (NT), a marker of oxidative stress, would elevate after vasospasm induced achtylcholine provocation test in patinets with vasospastic angina pectoris (VSAP). The serum NT levels significantly increased after coronary vasospasm induced by the test, suggensting that serum NT could be a biomarker of transient myocardial ischemia and could contribute to the development of VSAP.