The new therapeutic strategy for Chronic Kidney Disease involving CD147/Basigin

CD 147/Basigin是一种糖基化的跨膜蛋白，在细胞的生存、侵袭和转移中起重要作用。然而，关于糖尿病和自身免疫性疾病，涉及CD 147的分子机制仍然未知。随着CD 147识别活化的调节性T细胞（Treg），注意力已经扩展到自身免疫性疾病。产生白细胞介素（IL）-17的T细胞和调节性T细胞在SLE的发病机制中也起重要作用。在本研究中，缺乏CD 147通过STAT 3激活促进Th 17分化，最终导致狼疮肾炎的发展。另一方面，CD 147通过促进炎症细胞浸润，在缺血性肾损伤和肾纤维化中发挥有害作用。糖尿病也受到肾脏炎症中CD 147的影响。本研究结果可能有助于阐明糖尿病肾病和狼疮性肾炎的发病机制。

CD147/Basigin, a glycosylated transmembrane protein, plays important roles of cell survival, invasion and metastasis. With regard to diabetes and autoimmune diseases, however, the molecular mechanisminvolving CD147 remains unknown. As CD147 identifies activated regulatory T cell (Treg), the attention has become extended to the autoimmune diseases. Interleukin (IL)-17 producing T cell and Treg also serve important roles in the pathogenesis of SLE. In the present study, lack of CD147 promotes Th17 differentiation through the STAT3 activation, eventually leading to the development of lupus nephritis. On the other hand, CD147 play deleterious effects in renal inflammation caused by ischemia and renal fibrosis through the enhanced infiltration of inflammatory cells. Diabetes is also influenced by CD147 in renal inflammation. Our results may shed light on the mechanisms underlying the pathogenesis of diabetes nephropathy and lupus nephritis.