Interstitial pathophysiology and angiogenesis and its imaging in myocardial ischemia and remodeling

本实验采用大鼠心肌缺血再灌注模型，研究了C-14-蛋氨酸摄取的动态变化及其机制。在再灌注后1天，C-14-甲硫氨酸和Tl-201摄取在风险区域中均减少。然而，再灌注后3天，观察到C-14-甲硫氨酸摄取增加，对应于仍然减少的Tl-201摄取的区域，并且C-14-甲硫氨酸摄取逐渐下降，直到28天。3-7天时的C-14-甲硫氨酸摄取面积与通过阳性CD 68染色证明的巨噬细胞浸润良好对应。抗α-SMA染色在第7天出现，之后CD 68染色逐渐被SMA染色所取代，这表明缺血和再灌注后早期的蛋氨酸摄取可能反映了炎症活动。心肌梗塞后早期的炎症显像可能对甲流有帮助。

We investigated the serial changes and mechanisms of C-14-methionine uptake in a rat model of myocardial ischemia and reperfusion. Both C-14-methionine and Tl-201 uptake were reduced in the area at risk at 1 day after reperfusion. However, 3 days after reperfusion, an increased C-14-methionine uptake was observed corresponding to the area of still reduced Tl-201 uptake, and the C-14-Methionine uptake gradually declined until 28 days. The C-14-methionine uptake area at 3-7 days corresponded well to the macrophage infiltrations demonstrated by positive CD68 staining. Anti alpha-SMA staining appeared at 7 days, after which CD68 staining was gradually replaced by the SMA staining, suggesting that methionine uptake in the early phase after ischemia and reperfusion might reflect inflammatory activity. Methionine imaging may be useful for inflammatory imaging early after myocardial infarction.