Prediction of PSA bounce after I-125 prostate brachytherapy

本研究的目的是确定前列腺癌患者接受I-125前列腺腔内放射治疗后PSA反弹的相关因素。经I-125前列腺近距离放射治疗后，定期检测PSA。PSA反弹被定义为比之前的PSA水平至少上升0.1 ng/ml，随后的下降等于或小于最初的最低点。结果，32%的患者出现PSA反弹。在年轻患者(67岁)中，PSA反弹的发生率明显更高。在多变量分析中，年龄与PSA反弹显著相关。

The purpose of the present study was to determine factors that were associated with PSA bounce after I-125 prostate brachytherapy for patients with prostate cancer. After I-125 prostate brachytherapy, PSA was examined periodically. PSA bounce was defined as a rise of at least 0.1 ng/ml greater than a previous PSA level with a subsequent decline equal to, or less than, the initial nadir. As a result, PSA bounce occurred in 32% of patients. The incidence of PSA bounce was significantly higher in younger patients (<=67 years). In multivariate analysis, age was significantly associated with PSA bounce.