An establishment of new tumor dormancy therapy based on regulation of radical scavenger

我们研究了新的抗氧化剂、α硫酸（ALA）和维生素E是否通过诱导细胞凋亡、自噬或细胞周期阻滞在体内和体外诱导其抗增殖作用，并分析了这些现象相关蛋白在HT-29人结肠癌细胞中的表达及其磷酸化。这些新的抗氧化剂通过G2/M细胞周期阻滞和自噬抑制HT-29细胞的增殖，而不是通过凋亡抑制HT-29细胞。新合成的ALA衍生物有望通过诱导自噬成为一种新的癌症治疗策略。

We investigated whether new antioxidants, alfa-lipoic acid (ALA) delivertives and vitamin E delivertives elicits its antiproliferative effects in vivo and in vitro by inducing apoptosis, autophagy or cell cycle arrest, and we analyzed the expression of proteins related to these phenomena and their phosphorylation in HT-29 human colon cancer cells. These new antioxidants inhibited the proliferation of HT-29 cells through the mechanisms of G2/M cell cycle arrest and autophagy but not that of apoptosis. The newly synthesized ALA derivative may be expected to become a novel cancer therapeutic strategy through its induction of autophagy.