A study for intraocular molecular mechanism and functional expression of tissue stem cells induced injury to the retina.

本研究与视网膜组织干细胞分化的调控机制有关，并利用眼病和视网膜损伤动物模型进行了分析。在视网膜损伤动物模型中应用非类固醇抗炎药，可以抑制移植的神经干细胞的神经胶质分化，并且属于IL-6超家族的CNTF的表达是一种炎性细胞因子。在使用眼病样本的分析中，淀粉样蛋白相关蛋白的炎性细胞因子、生长因子的表达增加，具体表现为白内障、青光眼和视网膜疾病。在视网膜色素上皮细胞培养分析中，已经揭示了NF-kB在视网膜脱离、视网膜前膜疾病、磷酸化信号Smad的参与下对玻璃体的转化诱导作用。

This study was related to the control mechanism differentiation of retinal tissue stem cells and was analyzed by using a sample eye disease and retinal injury animal model. It was possible to suppress glial differentiation of neural stem cells transplanted as well as the expression of CNTF belonging to the IL-6 superfamily is an inflammatory cytokine by a non-steroidal anti-inflammatory agent administered in the retinal injury animal model. Increased expression inflammatory cytokines, growth factors, of amyloid-related proteins was revealed cataract, glaucoma, and retinal disease in specific in the analysis using a sample eye disease. In retinal pigment epithelial cell culture analysis, the transformation-induced effect on the vitreous humor with retinal detachment, epiretinal membrane disease, involvement of phosphorylation signal smad, of NF-kB has been revealed.