regulatory mechanisms underlying proliferation, differentiation, migration and integration in transplanted retinal stem cells in diseased retinas

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The development of retinal regenerative therapy and its efforts to restore visual function in patients with significant visual impairment has recently drawn much attention. Our knowledge of regulatory mechanisms underlying proliferation, differentiation, migration and integration in transplanted progenitors in diseased retinas is far from satisfactory. We introduce our experiments and outline the hopes and problems of cell therapy for damaged and diseased retinas. One of our experiences effectively utilizes stable cell proliferation to prepare a sufficient amount of stem cell pool to establish a stem cell therapy.Wnt signaling may provide a novel strategy for stem cell therapy using adult retinal progenitors prepared from the ciliary margin. Furthermore, transplantation of progenitor cells into the damaged retina revealed that conditions in the host retina affect the fate of transplanted cells through the gp130-signaling pathway. Manipulating host microenvironments may therefore support the proper differentiation of transplanted progenitor cells into the retina for regenerative therapy.