The study for cell-cell interaction and molecular signals about maintenance of retina stem cell
The study for cell-cell interaction and molecular signals about maintenance of retina stem cell
批准号:
20592049
负责人:
FUKUSHIMA Mikiko
金额:
$3.0万
依托单位:
依托单位国家:
日本
项目类别:
Grant-in-Aid for Scientific Research (C)
财政年份:
2008
资助国家:
日本
项目状态:
已结题
起止时间:
2008 至 2010
中文摘要
对视网膜组织祖细胞进行分析,为视网膜再生治疗的临床应用奠定基础。该分子的寻找与视网膜祖细胞的增殖和分化有关,并通过使用敲除小鼠进行分析。阐明了硫酸乙酰肝素蛋白多糖对维持视网膜前体细胞分化的作用,以及通过gp130进行分化的分子信号的关系。
英文摘要
The retinal tissue progenitor cell was analyzed as a basic research for the clinical application of the retina regeneration therapy. The search for the molecule was related to proliferation and differentiation of the retinal progenitor cell, and was analyzed by using the knockout mouse. Then it was clarified to the maintenance of the retinal progenitor cell of the role of the heparan sulfate proteoglycan, and relations of the molecular signal through gp130 for the differentiation.
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Smad経路を介したヘパラン硫酸による前眼部発生
硫酸乙酰肝素通过 Smad 途径发育眼前节
DOI:
--
发表时间:
2008
期刊:
影响因子:
--
作者:
[Kawashima M, Kawakita T, Okada N, Ogawa Y, Dogru M, Nakamura S, Nakashima H, Shimmura S, Shinmura K, Tsubota K., 岩尾圭一郎]
通讯作者:
岩尾圭一郎
Suppression of choroidal neovascularization in lectin-like oxidized low-density lipoprotein receptor type 1-eficient mice.
凝集素样氧化低密度脂蛋白受体 1 型高效小鼠脉络膜新生血管的抑制。
DOI:
--
发表时间:
2009
期刊:
Invest Ophthalmol Vis Sci. 50
影响因子:
--
作者:
[Inomata Y, Fukushima M, Hara R, Takahashi E, Honjo M, Koga T, Kawaji T, Satoh H, Takeya M, Sawamura T, Tanihara H.]
通讯作者:
Tanihara H.
Heparan sulfate the key regulator of optic nerve guidance.
硫酸乙酰肝素是视神经引导的关键调节剂。
DOI:
--
发表时间:
2009
期刊:
影响因子:
--
作者:
[Tsubota K, Kawashima M, Inaba T, Dogru M, Ogawa Y, Nakamura S, Shinmura K, Higuchi A, Kawakita T., Inatani M.]
通讯作者:
Inatani M.
DOI:
10.1016/j.ijdevneu.2009.07.006
发表时间:
2009-11-01
期刊:
INTERNATIONAL JOURNAL OF DEVELOPMENTAL NEUROSCIENCE
影响因子:
1.8
作者:
[Fukushima, Mikiko, Setoguchi, Takao, Taga, Tetsuya]
通讯作者:
Taga, Tetsuya
Dynamic imaging of axonal transport in living retinal ganglion cells in vitro.
体外活体视网膜神经节细胞轴突运输的动态成像。
DOI:
10.1167/iovs.10-6435
发表时间:
2011
期刊:
Invest Ophthalmol Vis Sci.
影响因子:
--
作者:
[Takihara Y, Inatani M, Hayashi H, Adachi N, Iwao K, Inoue T, Iwao M, Tanihara H.]
通讯作者:
Tanihara H.
共 9 条
A study for intraocular molecular mechanism and functional expression of tissue stem cells induced injury to the retina.
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批准号:23592610
-
项目类别:Grant-in-Aid for Scientific Research (C)
-
资助金额:$3.33万
-
财政年份:2011
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负责人:FUKUSHIMA Mikiko
-
依托单位:
regulatory mechanisms underlying proliferation, differentiation, migration and integration in transplanted retinal stem cells in diseased retinas
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批准号:18591927
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项目类别:Grant-in-Aid for Scientific Research (C)
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资助金额:$2.51万
-
财政年份:2006
-
负责人:FUKUSHIMA Mikiko
-
依托单位:
海外基金