Mechanisms and roles of volume-sensitive anion channel activation mediated by chemical transmitters released in response to cell membrane stretch

本研究旨在探讨细胞膜拉伸时细胞释放的化学递质介导的体积敏感外向整流（VSOR）阴离子通道的激活机制，并阐明其在细胞体积调节、细胞形状改变和迁移中的作用。研究表明，ATP和谷氨酸的自分泌作用触发VSOR通道激活，这是由紧邻单个开放钙离子可渗透通道蛋白（称为“钙纳米结构域”）的细胞内钙离子浓度非常高的区域介导的。这一机制将为细胞形状变化过程中局部细胞体积的调控提供基础。该研究还揭示了在胚胎发育的大脑中，通过VSOR通道释放的牛磺酸对神经元迁移速度的调节。

This study was aimed at investigating the activation mechanism of the volume-sensitive outwardly rectifying (VSOR) anion channel mediated by chemical transmitters released from cells in response to cell membrane stretch and at elucidating its roles in cell volume regulation, cell shape changes and migration. The study revealed that autocrine actions of ATP and glutamate trigger VSOR channel activation mediated by very high intracellular calcium ion concentration regions in the immediate vicinity of individual open calcium ion-permeable channel proteins, called "calcium nanodomains". This mechanism would provide a basis for the regulation of local cell volume during cell shape changes. The study also uncovered the regulation of the speed of neuronal migration by taurine released through VSOR channels in the developing brain in embryos.