One-pot preparation of dendrimer-gold nanohybrids with controlled photothermal property and their application to cancer therapy

在本研究中，我们尝试开发具有可控尺寸和光热性质的树枝状聚合物-金纳米棒杂化物。以二硫键为核的聚乙二醇修饰的聚酰胺-胺树枝状大分子为模板，通过金纳米棒的形成，制备了具有小尺寸和高光热性能的杂化材料。在近红外光照射下，占据杂交体的癌细胞被有效地杀死，因此这些杂交体可能潜在地用作用于癌症光热疗法的纳米器件。

In this study, we attempted to develop dendrimer-gold nanorod hybrids with controlled size and photothermal property. The hybrids with small size and high photothermal property were prepared by formation of gold nanorod in the presence of polyethyelen glycol-modified polyamidoamine dendrimers with disulfide bond at the core. Cancer cells taking up the hybrids were killed effectively under near infrared light irradiation and hence these hybrids might be potentially useful as a nanodevice for photothermal therapy for cancer.