Supramolecular Assembly of Amphiphilic Mesogenic Compounds InducingApoptosis in a Human Solid Cancer Cell Line

我们研究了含有羟基的中间源化合物的抗癌活性。化合物对A549人肺腺癌细胞进行了抑癌实验。含有一个酚单元的三环杂环衍生物对细胞生长有明显的抑制作用。细胞周期分析表明，这些化合物可诱导细胞凋亡。为了确定这些衍生物对正常细胞的影响，在相同条件下，对WI-38人肺成纤维细胞系进行了实验。非常有趣的是，正常细胞的抑制被发现依赖于介生部分的核心结构。一些化合物选择性地诱导肿瘤细胞凋亡而不抑制正常细胞。

We investigated anti-cancer activity of mesogenic compounds possessing a hydroxyl group. The compounds were tested against A549 human lung adenocarcinoma cell line. Three ring heterocyclic derivatives containing a phenol unit showed significant suppression of the cell growth. The cell cycle analysis indicates that these compounds induce apoptosis. To determine the influence of these derivatives on normal cells, they were tested against WI-38 human lung fibroblast cell line under the same condition. Very interestingly, suppression of the normal cells was found to be dependent on the core structure of the mesogenic moiety. Some compounds induces apoptosis selectively against the tumor cell without suppressing the normal cell.