The research for immunotherapy used by gd T cells

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In this study, we found the increase of γδ T cells in the peripheral blood from pediatric living donor liver transplantation recipients. The feature of gd T cells from recipients is the oligoglonal expansion ; the TCR of γδ T cell showed Vd1 TCR and the variable region of Vδ1 chain showed mnoclonality. We succeeded the expansion of γδ T cell from PBMC of healthy volunteers in vitro, and those T cells showed the immunosuppressive activity. These immunosuppressive T cells will be applied to new immunosuppressive therapy by transfer of the cells.