The research for immunotherapy used by gd T cells

gd T细胞免疫治疗的研究

• 批准号: 21791249
• 负责人: YOSHIZAWA Atsushi
• 金额: $ 2.58万
• 依托单位: Kyoto University
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for Young Scientists (B)
• 财政年份: 2009
• 资助国家: 日本
• 起止时间: 2009 至 2010
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-21791249/
• 关键词: 肝移植; 移植免疫; γδT細胞; 免疫寛容

In this study, we found the increase of γδ T cells in the peripheral blood from pediatric living donor liver transplantation recipients. The feature of gd T cells from recipients is the oligoglonal expansion ; the TCR of γδ T cell showed Vd1 TCR and the variable region of Vδ1 chain showed mnoclonality. We succeeded the expansion of γδ T cell from PBMC of healthy volunteers in vitro, and those T cells showed the immunosuppressive activity. These immunosuppressive T cells will be applied to new immunosuppressive therapy by transfer of the cells.

在本研究中，我们发现了儿童活体肝移植受者外周血中γδ T细胞的增加。受体gd T细胞以寡聚体扩增为特征，γδ T细胞TCR为Vd1TCR，Vδ1链可变区呈单克隆性。我们成功地从健康志愿者PBMC中扩增出γδ T细胞，并显示出免疫抑制活性。这些免疫抑制性T细胞将通过细胞转移应用于新的免疫抑制治疗。