The research for immunotherapy used by gd T cells

在本研究中，我们发现了儿童活体肝移植受者外周血中γδT细胞的增加。受者的gd T细胞以低克隆扩增为特征，γδT细胞的TCR表现为VD1TCR，Vδ1链可变区呈单克隆性。我们在体外成功地从健康志愿者的外周血中扩增出γδT细胞，这些T细胞具有免疫抑制活性。这些免疫抑制T细胞将通过细胞转移应用于新的免疫抑制治疗。

In this study, we found the increase of γδ T cells in the peripheral blood from pediatric living donor liver transplantation recipients. The feature of gd T cells from recipients is the oligoglonal expansion ; the TCR of γδ T cell showed Vd1 TCR and the variable region of Vδ1 chain showed mnoclonality. We succeeded the expansion of γδ T cell from PBMC of healthy volunteers in vitro, and those T cells showed the immunosuppressive activity. These immunosuppressive T cells will be applied to new immunosuppressive therapy by transfer of the cells.