Protein delivery and targeting to neuronal cells and its fluorescence imaging

分子递送到中枢神经系统是诊断和治疗神经退行性疾病所必需的。在这项研究中，我们开发了一种利用狂犬病病毒糖蛋白衍生的RVG多肽将蛋白质输送到神经细胞的技术。我们还通过合成nAChR结合肽发现了新的多肽作为神经细胞的载体。这些多肽允许蛋白质和小分子探针选择性地内化到神经细胞中。

he molecular delivery to the central nervous system is required for the diagnosis and treatment of neurodegenerative diseases require. In this research, we developed a technique for protein delivery to neuronal cells using RVG peptide derived from rabies virus glycoprotein. We also discovered novel peptides as carriers to neuronal cells by synthesizing nAChR-binding peptides. These peptides allow the selective internalization of a protein and a small molecule probe into neuronal cells.