Clarification of the physiological role of vasopressin in acute and chronic arthritis: using transgenic animals

我们检测了急性伤害性刺激后c-fos-mRFP1融合基因在脊髓背角和室旁核的表达。C-fos-mRFP1转基因大鼠后爪注射福尔马林或TRPV4激动剂。我们观察到sc后mRFP1的荧光显著增加。注射福尔马林或TRPV4激动剂。这些转基因大鼠是研究中枢神经系统对伤害性应激反应的有用模型。

We examined the expression of the c-fos-mRFP1 fusion gene in dorsal horn of the spinal cord and the paraventricular nucleus after acute nociceptive stimulation by subcutaneous (s.c.) injection of formalin or TRPV4 agonist in hind paw of the c-fos-mRFP1 transgenic rats. We observed significant increases of mRFP1 fluorescence after s.c. injection of formalin or TRPV4 agonist. These transgenic rats are useful models to study central nervous system responses to nociceptive stress.