The association between TNF-α and apoptosis in urethral sphincter with aging

我们探讨了尿液中炎症因子（如TNF-α）与衰老的关系。在使用退役放血大鼠的实验中，尿道控制功能在分娩后随着年龄的增长而显著下降，并且已经认为分娩后的年龄减弱了尿道支持。另一方面，尿道细胞外基质（extracellualr matrix，ECMs）的转录本随增龄而显著减少，而炎性细胞因子的转录本在青年组和老年组之间无显著变化。随着年龄的增长，ECM的减少可能会降低尿道支持系统的刚度和弹性，并可能是老年人，产妇SUI的一部分。

We explored the association between urinary continence mechanism and inflammatory cytokines (e.g. TNF-α) with aging. In the experiments using retired bleeder rat, urethral continent functions significantly decreased with aging after child-birth, and it has been considered that aging after child-birth attenuated urethral support. On the other hand, transcripts of extracellualr matrixs (ECMs) in urethra were significantly decreased with aging, although there were no significant changes in those of inflammatory cytokinesbetween young groups and aged groups. Reduction of ECM with aging might attenuate stiffness and elasticity of urethral support system, and may be a part of SUI in elderly, parous women.