Plasma ATP triggers inflammation in SIRS

在系统性炎症综合征反应（SIRS）患者中，血浆ATP水平显著高于健康对照组（HC）。在SIRS中，在全身缺血再灌注损伤引起炎症的心脏骤停综合征（PCAS）患者中，非幸存者的血浆ATP高于幸存者和HC。此外，PCAS中ATP水平与APACHE评分相关。脓毒症患者中性粒细胞活化（CD11b表达）明显高于HC患者，且CD11b的平均荧光强度与血浆ATP相关。这些数据表明，受损细胞或激活的炎症细胞释放ATP通过ATP受体刺激中性粒细胞并引发SIRS的炎症。

In systemic inflammatory syndrome response (SIRS) patients, plasma ATP levels were significantly higher than healthy controls (HC). Among SIRS, in post cardiac arrest syndrome (PCAS) patients, that whole-body ischemic reperfusion injury causes inflammation, plasma ATP was higher in non-survivors compared to survivors and HC. Besides, the ATP levels in PCAS correlate with APACHE score. In sepsis patients, neutrophil activation (CD11b expression) was significantly higher than in HC and the mean florescence intensity of CD11b correlates with plasma ATP. These data suggest that ATP release from damaged cells or activated inflammatory cells stimulates neutrophils via ATP receptors and triggers inflammation in SIRS.