VEGF as a Potential Candidate for Developing Novel Therapy and Diagnosis for MODS in Sepsis: Development of microcirculation-based therapeutic and diagnostic approach in sepsis

我们前瞻性研究了血管生成因子及其可溶性受体与器官功能障碍的关系，以及弥散性血管内凝血（DIC）诱导的血小板消耗、凝血酶生成和组织缺氧对血管生成因子及其可溶性受体表达的影响。我们发现，VEGF，sVEGFR 1，Ang 2，Ang 1/Ang 2，特别是Ang 2，可能在DIC相关的脓毒症MODS的发展中起作用，并且VEGF，sVEGFR 1和Ang 2血清水平与DIC诱导的血小板消耗，凝血酶生成和血乳酸水平的程度相关。

We prospectively studied(1) the relationships between angiogenic factors, their soluble receptors and organ dysfunction and(2) the effects of disseminated intravascular coagulation (DIC)-induced platelet consumption, thrombin generation, and tissue hypoxia on the expression of the factors and receptorsFifty patients with sepsis were classified into two subgroups: 37 patients with DIC and 13 patients without DIC. We found, VEGF, sVEGFR1, Ang2, and Ang1/Ang2, especially Ang2, may have roles in the development of MODS in sepsis associated with DIC, and VEGF, sVEGFR1, and Ang2 serum levels correlated with the extent of DIC-induced platelet consumption, thrombin generation, and blood lactate levels.